HIV-1 protein p17 and heparin 1 Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists
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چکیده
Background: HIV-1 p17 binds heparin and heparan sulfate proteoglycans of the cell surface. Results: heparin/p17 interaction occurs through heparin sulfate groups and a linear basic motif of p17 N-terminus, also involved in p17/CXCR1 interaction. Conclusion: targeting the basic motif inhibits p17/receptors interaction and consequent biological activities. Significance: heparin-like molecules represent template for the development of new treatments of p17-dependent/AIDS-associated pathologies.
منابع مشابه
Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists.
Once released by HIV(+) cells, p17 binds heparan sulfate proteoglycans (HSPGs) and CXCR1 on leukocytes causing their dysfunction. By exploiting an approach integrating computational modeling, site-directed mutagenesis of p17, chemical desulfation of heparin, and surface plasmon resonance, we characterized the interaction of p17 with heparin, a HSPG structural analog, and CXCR1. p17 binds to hep...
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تاریخ انتشار 2012